Triple targeting host–guest drug delivery system based on lactose-modified azocalix[4]arene for tumor ablation
Juanjuan Li, Rui-Xue Rong, Yan Yang, Zong‐Ying Hu, Bing Hu, Yingying Zhao, Hua‐Bin Li, Xin‐Yue Hu, Ke‐Rang Wang, Dong‐Sheng Guo
Abstract
The supramolecular nanoformulation DOX@LacAC4A integrates passive, active and stimuli-responsive targeting capabilities. It can improve drug accumulation at tumor sites and effectively suppress the growth of tumor cells.
Topics & Concepts
Drug deliverySupramolecular chemistryDrugTargeted drug deliveryTumor ablationAblationCancer researchHost (biology)NanotechnologyMaterials scienceChemistryMedicinePharmacologyBiologyCrystallographyInternal medicineCrystal structureEcologySupramolecular Chemistry and ComplexesNanoparticle-Based Drug DeliverySupramolecular Self-Assembly in Materials