Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1
Min Zhu, Zi Liang, Jun Pan, Xing Zhang, Renyu Xue, Guangli Cao, Xiaolong Hu, Chengliang Gong
Abstract
. HBV_circ_1 was confirmed to interact with cyclin-dependent kinase 1 (CDK1) to regulate cell proliferation. These results suggest that HCC progression may be promoted by interaction of HBV_circ_1 with CDK1. Our data not only showed a novel clue to understand carcinogenesis and progress of HBV-related HCC but also provided a new target for the development of therapeutic drugs.
Topics & Concepts
Hepatocellular carcinomaHepatitis B virusCarcinogenesisCyclin B1Cyclin-dependent kinase 1Cancer researchCircular RNACyclin E1VirologyMedicineVirusCell cycleBiologyCyclinmicroRNAInternal medicineCancerGeneBiochemistryCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research