Molecular Evolution of Attachment Glycoprotein (G) and Fusion Protein (F) Genes of Respiratory Syncytial Virus ON1 and BA9 Strains in Xiamen, China
Yongpeng Sun, Si-Yu Lei, Ying-Bin Wang, Yizhen Wang, Hong-Sheng Qiang, Yifan Yin, Ze-Min Jiang, Min Zhu, Xiaoli Chen, Huiming Ye, Zizheng Zheng, Ningshao Xia
Abstract
Monitoring the amino acid diversity of the RSV G and F genes helps us to find the novel genotypes, key antigenic mutations affecting antigenicity, or neutralizing antibody-resistant variants produced by natural evolution. In this study, we analyzed the molecular evolution of G and F genes from RSV strains circulating in Xiamen, China. These data provide new insights on local and global transmission and could inform the development of control measures for RSV infections.
Topics & Concepts
BiologyVirusVirologyAntigenicityGenotypeGeneViral evolutionPopulationAntigenic variationMolecular evolutionGenetic diversityAntigenGeneticsPhylogeneticsRNAMedicineEnvironmental healthRespiratory viral infections researchAnimal Virus Infections StudiesVirology and Viral Diseases