CompassR-guided recombination unlocks design principles to stabilize lipases in ILs with minimal experimental efforts
Haiyang Cui, Subrata Pramanik, Karl‐Erich Jaeger, Mehdi D. Davari, Ulrich Schwaneberg
Abstract
CompassR-guided recombination proved that intrinsic lipase stability and strengthening of hydration shells of enzymes to keep them intact are two synergistic design principles to preserve enzymatic activity in ionic liquids.
Topics & Concepts
LipaseRecombinationEnzymeChemistryIonic liquidStability (learning theory)Rational designIonic bondingOrganic chemistryMaterials scienceBiochemistryNanotechnologyCatalysisComputer scienceIonMachine learningGeneEnzyme Catalysis and ImmobilizationElectrochemical sensors and biosensorsMicrobial Metabolic Engineering and Bioproduction