Bridging D–A type photosensitizers with the azo group to boost intersystem crossing for efficient photodynamic therapy
Boyi Hao, Jiaxin Wang, Chao Wang, Ke Xue, Minghui Xiao, Shuyi Lv, Chunlei Zhu
Abstract
isomerization upon UV irradiation to form emissive aggregates by shutting down the ISC channel. By virtue of the fluorescence turn-on property of unbound Azo-TPA-Th(+), we propose a straightforward method to directly discern the effective photodynamic bactericidal dose without performing the tedious plate-counting assay. This study opens a brand-new avenue for the design of advanced PSs with both strong ROS generation and stimuli-responsiveness, holding great potential in high-quality PDT with rapid prediction of the therapeutic outcome.
Topics & Concepts
Intersystem crossingPhotodynamic therapyAzobenzeneChemistryPhotochemistryCombinatorial chemistryReactive oxygen speciesIrradiationMoleculeOrganic chemistryBiochemistryExcited stateSinglet stateNuclear physicsPhysicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies