An Efficient Synthesis of Phthalimides and Their Biological Activities
Hamida Jelali, Lamjed Mansour, Éric Deniau, Mathieu Sauthier, Naceur Hamdi
Abstract
Practical and efficient synthesis of phthalimides compounds 3 were described and characterized. The synthesized compounds were screened for their antimicrobial activities against gram-positive bacterial strains (Micrococcus luteus, Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus), a gram-negative bacterial strain (Salmonella typhimurium) and a fungus (Candida albicans). Cytotoxicity studies of the of phthalimides 3 were conducted in two human cancer cell lines, MDA-MB-231 and MCF-7.
Topics & Concepts
ChemistryPhthalimidesMicrococcus luteusListeria monocytogenesBacillus cereusAntimicrobialMicrobiologyStaphylococcus aureusSalmonellaCandida albicansCytotoxicityGram-positive bacteriaChalconeBacteriaEscherichia coliBiochemistryIn vitroStereochemistryOrganic chemistryBiologyGeneticsGenePhthalimideSynthesis and pharmacology of benzodiazepine derivativesSynthetic Organic Chemistry MethodsCancer therapeutics and mechanisms