Malignant transformation of a dysembryoplastic neuroepithelial tumor presenting with intraventricular hemorrhage
Hirotaka Takita, Taro Shimono, Takehiro Uda, Hayato Ikota, Toshiyuki Kawashima, Daisuke Horiuchi, Eisaku Terayama, Taro Tsukamoto, Yukio Miki
Abstract
Dysembryoplastic neuroepithelial tumors (DNTs) are benign brain tumors classified as grade 1 in the 2021 World Health Organization (WHO) classification of central nervous system tumors. DNTs rarely undergo malignant transformation and cause symptomatic intracranial hemorrhage. We report a case of malignant transformation of DNT presenting with intraventricular hemorrhage and review the literature on malignant transformation of DNTs. An 18-year-old woman with a history of epilepsy presented with a sudden headache and vomiting. Radiological examination revealed a mass lesion in the left parietal lobe and intraventricular hemorrhage. The patient underwent an emergency craniotomy for brain tumor resection. The lesion was pathologically diagnosed as a malignant transformation of DNT. She had been followed up without tumor recurrence for 2 years after surgery.