Enantioselective synthesis of vicinal diamines and β-amino amides by NiH-catalyzed hydroamidation of alkenyl amides
Xun Tian, Shengzu Duan, Yuan Ma, Ailin Pan, Yamiao Meng, Guogang Deng, Hongbin Zhang, Xiaodong Yang
Abstract
The first NiH/BOX-catalyzed enantioselective hydroamidation of alkenyl amides is reported. This method provides chiral vicinal diamines and β-amino amides, including the derivatization of bioactive molecules, and the preparation of chiral Nicaraven.
Topics & Concepts
ChemistryVicinalEnantioselective synthesisCatalysisOrganic chemistryStereochemistryChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic Chemistry