Diversity-Oriented Synthesis of Fluoromethylated Arenes via Palladium-Catalyzed C–H Fluoromethylation of Aryl Iodides
Yiming Du, Shuxin Chen, Ao Huang, Yihan Chen, Yun‐Lin Liu, Gaopeng Song, Ri‐Yuan Tang, Hanhong Xu, Guangkai Yao, Zhaodong Li
Abstract
Herein we report the first versatile and expeditious method for the site-selective C–H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of fluoromethylated arenes. This methodology features the use of the low-cost industrial raw material CH2IF as the fluoromethyl source, an excellent functional group tolerance, and a broad ipso termination scope and can be expanded to the late-stage modification of biorelevant molecules.
Topics & Concepts
ChemistryArylNorbornenePalladiumCatalysisCombinatorial chemistryFunctional groupFunctional diversityToolboxMoleculeOrganic chemistryCopolymerComputer scienceEcologyAlkylProgramming languagePolymerBiologyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions