Synthesis and biological evaluation of 2′-Aminochalcone: A multi-target approach to find drug candidates to treat Alzheimer’s disease
Renata P. Sakata, Giorgio Antoniolli, Marcelo Lancellotti, Daniel Fábio Kawano, Euzébio Guimarães Barbosa, Wanda P. Almeida
Topics & Concepts
ChemistryAcetylcholinesteraseEnzymeIn silicoBiochemistryIC50ThioflavinPeptideDrugAchéDocking (animal)Amyloid (mycology)CholinergicIn vitroPharmacologyActive siteADMEStereochemistryAlzheimer's diseaseDiseaseNeuroscienceInternal medicineNursingInorganic chemistryBiologyGeneMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments