Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease
John Bosco Ruganzu, Xiaoqian Peng, Yingying He, Xiangyuan Wu, Quzhao Zheng, Bo Ding, Chengheng Lin, Hongsong Guo, Zikang Yang, Xiao Zhang, Weina Yang
Topics & Concepts
TREM2NeuroinflammationDownregulation and upregulationMicrogliaTLR4Cell biologyTumor necrosis factor alphaMAPK/ERK pathwayAstrocytosisp38 mitogen-activated protein kinasesBiologySignal transductionNeuroscienceImmunologyInflammationCentral nervous systemGeneBiochemistryNeuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysNeurological Disease Mechanisms and Treatments