Can the RBD mutation R346X provide an additional fitness to the “variant soup,” including offspring of BQ and XBB of SARS-CoV-2 Omicron for the antibody resistance?
Srijan Chatterjee, Manojit Bhattacharya, Kuldeep Dhama, Sang‐Soo Lee, Chiranjib Chakraborty
Abstract
The COVID-19 pandemic has resulted in nearly billions of infected cases and millions of deaths. Monoclonal antibodies (mAbs), antiviral drugs, vaccines, and several non-pharmaceutical interventions have been employed to control the virus’s spread and diminish the disease’s harms.1,2,3,4 However, antibody escape or resistance is a significant concern for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, which has been reported from time to time.5,6,7 Spike mutations in the variants and subvariants of SARS-CoV-2 are reported as a significant cause of antibody resistance.
Topics & Concepts
ScopusRepurposingCoronavirus disease 2019 (COVID-19)PandemicMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyTraditional medicineMEDLINEInternal medicineBiologyDiseaseEcologyInfectious disease (medical specialty)BiochemistrySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies