Pyruvate kinase M2 regulates fibrosis development and progression by controlling glycine auxotrophy in myofibroblasts
Ganesh Satyanarayana, Ravi Chakra Turaga, Malvika Sharma, Siming Wang, Falguni Mishra, Guangda Peng, Xiaonan Deng, Jenny J. Yang, Zhi‐Ren Liu
Abstract
Our study uncovers a novel role of PKM2 in tissue/organ fibrosis, suggesting a possible strategy for treatment of fibrotic diseases using PKM2 activator.
Topics & Concepts
MyofibroblastPKM2FibrosisAnaerobic glycolysisCancer researchFibroblastPyruvate kinaseChemistryGlycolysisBiologyCell biologyBiochemistryPathologyMedicineMetabolismIn vitroFibroblast Growth Factor ResearchMedical Imaging and Pathology StudiesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis