Test-Negative Study Designs for Evaluating Vaccine Effectiveness
Natalie E. Dean, Avnika B. Amin
Abstract
This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the Omicron variant.
Topics & Concepts
MedicineObservational studyTest (biology)Research designStatisticsInternal medicinePaleontologyBiologyMathematicsSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologySARS-CoV-2 detection and testing