Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
Penélope Saldanha Marinho, Antônio José Lêdo Alves da Cunha, Leila Chimelli, Elyzabeth Avvad Portari, Felipe Andreiuolo, P.S. Oliveira, Mayara Abud Mendes, Ismael C. Gomes, Letícia R. Q. Souza, Marília Zaluar P. Guimarães, Suzan Menasce Goldman, Mariana Barros Genuíno de Oliveira, Stevens K. Rehen, Joffre Amim, Fernanda Tovar‐Moll, Arnaldo Prata‐Barbosa
Abstract
SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.