Adaptive Mutation in the Main Protease Cleavage Site of Feline Coronavirus Renders the Virus More Resistant to Main Protease Inhibitors
Zhe Jiao, Yuanyuan Yan, Yixi Chen, Gang Wang, Xiaowei Wang, Lisha Li, Mengfang Yang, Xiaoshuai Hu, Yilin Guo, Yuejun Shi, Guiqing Peng
Abstract
and attenuated the therapeutic effect of GC376 in an animal model of FIPV infection. Our research explains the evolutionary characteristics of coronaviruses under antiviral drugs, which is helpful for a more comprehensive understanding of the molecular basis of virus resistance and provides important basic data for the effective prevention and control of CoVs.
Topics & Concepts
BiologyVirologyProteaseCoronavirusCleavage (geology)VirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MutationCoronavirus disease 2019 (COVID-19)NS2-3 protease2019-20 coronavirus outbreakViral replicationEnzymeGeneticsGeneBiochemistryInfectious disease (medical specialty)Fracture (geology)DiseasePaleontologyMedicinePathologyOutbreakSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesVirus-based gene therapy research