ROS-dependent inhibition of the PI3K/Akt/mTOR signaling is required for Oroxylin A to exert anti-inflammatory activity in liver fibrosis
Min Shen, Mei Guo, Zhenyi Wang, Yujia Li, Desong Kong, Jiangjuan Shao, Shanzhong Tan, Anping Chen, Feng Zhang, Zili Zhang, Shizhong Zheng
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayProtein kinase BPharmacologyInflammationSignal transductionFibrosisChemistryCancer researchCell biologyBiologyMedicineImmunologyApoptosisBiochemistryInternal medicineLiver physiology and pathologyLiver Disease Diagnosis and TreatmentAutophagy in Disease and Therapy