Click chemistry in the development of PROTACs
Ce Yang, Ravi Tripathi, Binghe Wang
Abstract
assembly for improved delivery, conjugation with a targeting group for selectivity, rapid synthesis for linker optimization, and lysosomal degradation of extracellular and membrane-associated proteins. We also examine reaction kinetics issues whenever possible or warranted.
Topics & Concepts
Click chemistryComputer scienceChemistryCombinatorial chemistryProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis