Three-dimensional mapping of hepatic lymphatic vessels and transcriptome profiling of lymphatic endothelial cells in healthy and diseased livers
Songlin Huang, Borui Li, Zheng Liu, Mengli Xu, Dong Lin, Jiahong Hu, Dongjian Cao, Qi Pan, Jing Zhang, Jing Yuan, Qingming Luo, Zhihong Zhang
Abstract
We proposed an STSI-Ab method for selectively labeling hepatic LVs, distinguishing the hepatic LVs from other vessels, and mapping their 3D structure. This study opens an avenue for understanding hepatic lymphatic structure and it will be very beneficial to the study of hepatic LyEC functions.
Topics & Concepts
Lymphatic systemHepatic stellate cellPathologyLymphatic EndotheliumHepatic fibrosisBiologyLymphatic vesselFibrosisMedicineGeneticsMetastasisCancerLymphatic System and DiseasesSpaceflight effects on biologyNeonatal Respiratory Health Research