Planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes via palladium(0)-catalyzed C-H functionalization of trifluoroacetimidoyl chlorides
An‐An Zhang, Chao Chen, Yushen Gao, Mingyang Mo, Renzeng Shen, Yuheng Zhang, Naoki Ishida, Masahiro Murakami, Lantao Liu
Abstract
Catalytic enantioselective synthesis of planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes has been achieved through Pd(0)-catalyzed C-H functionalization with trifluoroacetimidoyl chlorides as electrophilics. With commercially available ligand and palladium precursor, the reaction proceeds smoothly generating 2-perfluoroalkylated quinoline-fused ferrocenes in high yields and enantioselectivities.
Topics & Concepts
QuinolinePalladiumSurface modificationTrifluoromethylChemistryCatalysisEnantioselective synthesisCombinatorial chemistryLigand (biochemistry)Medicinal chemistryOrganic chemistryReceptorAlkylBiochemistryPhysical chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms