CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury
Tingting Qi, Xiaoming Xu, Yongzhen Guo, Yunlong Xia, Peng Lü, Congye Li, Fengyue Ding, Chao Gao, Miaomiao Fan, Min Yu, Huishou Zhao, Yuan He, Wenli Li, Chunxu Hai, Erhe Gao, Xing Zhang, Feng Gao, Yanhong Fan, Wenjun Yan, Ling Tao
Abstract
We demonstrate for the first time that CSF2RB overexpression optimizes the efficacy of intravenously delivered MSCs in the treatment of ischemic heart injury by increasing the response of the MSCs to a CSF2 gradient and CSF2RB-dependent STAT5/RNF4 activation.
Topics & Concepts
Mesenchymal stem cellStromal cellMedicineHoming (biology)ContractilityIschemiaCell therapyAdipose tissueEjection fractionApoptosisHeart failureCancer researchStem cellPathologyInternal medicineChemistryBiologyCell biologyEcologyBiochemistryMesenchymal stem cell researchCardiac Fibrosis and RemodelingCardiovascular Function and Risk Factors