Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense
Carla Di Chio, Santo Previti, Giorgio Amendola, Rahul Ravichandran, Annika Wagner, Sandro Cosconati, Ute A. Hellmich, Tanja Schirmeister, Maria Zappalà, Roberta Ettari
Topics & Concepts
DipeptideChemistryNitrileAntiparasiticTrypanosoma bruceiEC50StereochemistryTrypanosoma brucei rhodesienseStructure–activity relationshipProteaseCombinatorial chemistryBiochemistryIn vitroPeptideEnzymeOrganic chemistryGeneMedicinePathologyTrypanosoma species research and implicationsCarbohydrate Chemistry and SynthesisSynthesis and Biological Evaluation