Selective Electrochemical Sensing Platform Based on the Synergy between Carbon Black and Single-Crystalline Bismuth Sulfide for Rapid Analysis of Antipyretic Drugs
Raja Nehru, Yung‐Fu Hsu, Sea‐Fue Wang, Chiu‐Wen Chen, Cheng‐Di Dong
Abstract
Nanomaterials are of significant interest in acetaminophen (APAP) detection in pharmaceutical samples. Herein, a carbon black/single-crystalline rodlike bismuth sulfide (CB/Bi2S3) composite prepared by an ultrasonic method is reported and utilized for the rapid analysis of APAP. The highly oriented edge reactive sites of the CB/Bi2S3 composite promoted synergy and good electrochemical sensing performance with a fast electron transfer rate and low overpotential (0.35 V). Therefore, a CB/Bi2S3 composite-modified glassy carbon electrode (GCE) was applied to the selective determination of APAP by the voltammetric technique. The CB/Bi2S3 composite-modified electrode showed the lowest limit of detection of APAP (1.9 nM) with excellent sensitivity. The proposed CB/Bi2S3/GCE platform exhibited high selectivity, excellent stability (87.15%), and reproducibility. Also, the CB/Bi2S3/GCE sensor was then successfully used to analyze an APAP pharmaceutical sample and exhibited satisfactory outcomes. Therefore, the CB/Bi2S3-modified GCE sensor platform would be a low-cost and robust GCE electrode material for APAP detection.