ILC3s control airway inflammation by limiting T cell responses to allergens and microbes
Fei Teng, Roser Tachó‐Piñot, Biin Sung, Donna L. Färber, Stefan Worgall, Hamida Hammad, Bart N. Lambrecht, Matthew R. Hepworth, Gregory F. Sonnenberg
Abstract
ILC3s limit a concomitant Th17 cell response and airway neutrophilia. This exacerbated Th17 cell response requires exposure of the lung to microbial stimuli, which can be found associated with house dust mites. These findings demonstrate a critical role for antigen-presenting ILC3s in orchestrating immune tolerance in the airway by restricting pro-inflammatory T cell responses to both allergens and microbes.
Topics & Concepts
ImmunologyInnate lymphoid cellBiologyHouse dust miteImmune systemMHC class IIT cellAllergyImmunityAllergenIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisImmune Cell Function and Interaction