Inhibition of MyD88 by a novel inhibitor reverses two-thirds of the infarct area in myocardial ischemia and reperfusion injury.
Miao Yan, Zuochuan Ding, Zhimiao Zou, Yang Yang, Min Yang, Xiaoqian Zhang, Zeyang Li, Liang Zhou, Limin Zhang, Xue Zhang, Dunfeng Du, Fengchao Jiang, Ping Zhou
Abstract
. Thus, our findings highlight TJ-M2010-5 as a potential therapeutic agent for MIRI treatment.
Topics & Concepts
Proinflammatory cytokineTumor necrosis factor alphaDownregulation and upregulationPharmacologyCD86InflammationFlow cytometryReperfusion injuryInterleukinMedicineBlotChemistryCancer researchCell biologyIschemiaImmunologyBiologyInternal medicineCytokineBiochemistryT cellImmune systemGeneCardiac Ischemia and ReperfusionCardiac Fibrosis and RemodelingSignaling Pathways in Disease