<i>In vitro</i> and <i>in silico</i> studies of SARS-CoV-2 main protease M<sup>pro</sup> inhibitors isolated from <i>Helichrysum bracteatum</i>
Gehad Abdel Wahab, Walaa S Aboelmaaty, M. Lahloub, Amal Sallam
Abstract
Compounds isolated and identified from Helichrysum bracteatum leaves showed promising in vitro inhibitory activities against SARS-CoV-2 main protease (M pro ). Thus, could be considered suitable drug leads for developing anti-COVID-19 therapeutics.
Topics & Concepts
In silicoIn vitroProteaseChemistryVirologyBiologyStereochemistryBiochemistryEnzymeGeneMedicinal Plants and NeuroprotectionPhytochemistry and Bioactivity StudiesComputational Drug Discovery Methods