Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure
Katelyn Arnold, Yongmei Xu, Erica Sparkenbaugh, Miaomiao Li, Xiaorui Han, Xing Zhang, Ke Xia, Mark Piegore, Fuming Zhang, Xiaoxiao Zhang, Mike Henderson, Vijayakanth Pagadala, Guowei Su, Lisi Tan, Pyong Woo Park, Richard T. Stravitz, Nigel S. Key, Robert J. Linhardt, Rafał Pawliński, Ding Xu, Jian Liu
Abstract
-acetyl cysteine for late-presenting patients. Synthetic HS provides a potential approach for the treatment of APAP-induced ALF.
Topics & Concepts
Proinflammatory cytokineHeparan sulfateHMGB1Liver failureAcetaminophenRage (emotion)PharmacologyMedicineDrugInflammationChemistryImmunologyHeparinBiologyInternal medicineNeuroscienceAdvanced Glycation End Products researchDrug-Induced Hepatotoxicity and ProtectionAlcohol Consumption and Health Effects