LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria <i>In Vitro</i> and <i>In Vivo</i>
Juanjuan Su, Haimeng Li, Jingyang Hu, Danni Wang, Fengchao Zhang, Zheng Fu, Feng Han
Abstract
, as well as a protective effect in a Staphylococcus aureus infection mouse model. The antibacterial mechanisms included membrane disruption and permeation. This study advanced the field of antibacterial chemokine research in fish and also suggested a new strategy for exploring novel AMPs. The novel peptide lcCCL28-25 may prove to be an effective antibacterial agent.
Topics & Concepts
ChemokineGramMicrobiologyAntimicrobialImmune systemIn vivoIn vitroBiologyGram-negative bacteriaBacteriaGram-positive bacteriaImmunologyEscherichia coliBiochemistryGeneGeneticsAntimicrobial Peptides and ActivitiesAquaculture disease management and microbiotaImmune Response and Inflammation