Supramolecular palladium complexes based on guanidinium pillar[5]arene for cancer therapy
Yafei Wen, Xiaojiao Di, Zelong Chen, Xuxu Zhang, Zhichao Pei, Yuxin Pei
Abstract
, was used to encapsulate doxorubicin to form G-Pd@DOX. The nanoparticles exhibit responsiveness to glutathione, controlled drug release, the ability to damage mitochondria, and potent anticancer activity while maintaining low toxicity towards normal cells. This work provides a good example for the application of pillararene-based palladium complexes in cancer therapy and is significant for the discovery of new medicines from supramolecular coordination complexes.
Topics & Concepts
PillarPalladiumSupramolecular chemistryCancer therapyChemistryCombinatorial chemistryCancerPolymer chemistryStereochemistryCrystallographyOrganic chemistryCrystal structureMedicineInternal medicineCatalysisStructural engineeringEngineeringSupramolecular Chemistry and ComplexesLanthanide and Transition Metal ComplexesAdvanced NMR Techniques and Applications