Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure
Jinxian Lin, Chi-Yu Xu, Xin-Mou Wu, Lin Che, Tingyu Li, Su-Min Mo, Dongbei Guo, Zhong‐Ning Lin, Yu‐Chun Lin, Yu‐Chun Lin
Topics & Concepts
LipotoxicityLysosomeNPC1mTORC1BiologyMitochondrionCell biologyLiver injuryChemistryBiochemistryPharmacologyEndocrinologySignal transductionPI3K/AKT/mTOR pathwayEndosomeInsulinIntracellularEnzymeInsulin resistanceCell death mechanisms and regulationAutophagy in Disease and TherapyCellular transport and secretion