Reassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery
Yuxin Chen, Lulu Han, Xiaoyan Qiu, Meng Wang, Zheng Chen, Ying Cai, Yong Xin, Yan-Fang Lv, Ankang Hu, Dafei Chai, Liantao Li, Huizhong Li, Junnian Zheng, Gang Wang
Abstract
but do not affect neutrophils' function, such as chemotaxis and activation. In a murine tumor model, we further proved that local radiotherapy (RT) induced inflammation activated peripheral neutrophils to capture venous infused NP-abPTX and carry them into tumor tissue. As compared to abPTX, infusion of NP-abPTX dramatically enhanced inhibition of tumor growth treated by local RT and mitigated hematotoxicity. Therefore, our study demonstrated a novel strategy to mitigate side-effects and to improve tumor killing efficacy of abPTX through neutrophil-mediated targeting drug delivery.