Indole microbial intestinal metabolites expand the repertoire of ligands and agonists of the human pregnane X receptor
Peter Illéš, Kristýna Krasulová, Barbora Vyhlídalová, Karolína Poulíková, Adéla Marcalíková, Petra Pečinková, Natália Sirotová, Radim Vrzal, Sridhar Mani, Zdeněk Dvořák
Topics & Concepts
Pregnane X receptorReporter geneIndole testReceptorG protein-coupled receptorChemistryTryptophanBiologySignal transductionBiochemistryPharmacologyGeneNuclear receptorTranscription factorGene expressionAmino acidPharmacogenetics and Drug MetabolismHormonal Regulation and HypertensionDrug Transport and Resistance Mechanisms