Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
Berislav V. Zloković, Rebecca F. Gottesman, Kenneth E. Bernstein, Sudha Seshadri, Ann C. McKee, Heather M. Snyder, Steven M. Greenberg, Kristine Yaffe, Chris B. Schaffer, Chun Yuan, Timothy M. Hughes, Mat J.A.P. Daemen, Jeff D. Williamson, Hector M. González, Julie A. Schneider, Cheryl L. Wellington, Zvonimir S. Katušić, Luke E. Stoeckel, James I. Koenig, Roderick A. Corriveau, Lawrence J. Fine, Zorina S. Galis, Jared P. Reis, Jacqueline D. Wright, Jue Chen
Abstract
Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.