Proflavine and zinc chloride “team chemistry”: combining antibacterial agents <i>via</i> solid-state interaction
Cecilia Fiore, Oleksii Shemchuk, Fabrizia Grepioni, Raymond J. Turner, Dario Braga
Abstract
Mechanochemical and solution reaction of ZnCl<sub>2</sub> with proflavine yields the antimicrobials [HPF]<sub>2</sub>[ZnCl<sub>4</sub>]·H<sub>2</sub>O and ZnCl<sub>3</sub>(HPF), more active, with respect to the separate components and the AgNO<sub>3</sub> standard, towards <italic>P. aeruginosa</italic>, <italic>E. coli</italic> and <italic>S. aureus</italic>.
Topics & Concepts
ChemistryProflavineZincSolid-stateInorganic chemistryPhysical chemistryOrganic chemistryBiochemistryDNACrystallography and molecular interactionsPhenothiazines and Benzothiazines Synthesis and ActivitiesMetal complexes synthesis and properties