Copper-mediated peptide arylation selective for the N-terminus
Mary K. Miller, Haopei Wang, Kengo Hanaya, Olivia Zhang, Alex Berlaga, Zachary T. Ball
Abstract
-electron withdrawing groups for copper-mediated amine arylation of the N-terminus under mild conditions and primarily aqueous solvent. The method adds to the toolkit of boronic acid reagents for polypeptide modification under mild conditions in water that shows complete selectivity for the N-terminus in the presence of lysine side chains.
Topics & Concepts
PeptideSulfonamideCombinatorial chemistryReactivity (psychology)ChemistryStereochemistryBiochemistryMedicinePathologyAlternative medicineChemical Synthesis and AnalysisClick Chemistry and ApplicationsPeptidase Inhibition and Analysis