Visible-Light-Mediated Deoxyalkynylation of Activated Tertiary Alcohols
Muzi Li, Tao Liu, Jiajun Li, Hengchi He, Haotian Dai, Jin Xie
Abstract
In this paper, visible-light-induced deoxyalkynylation of activated tertiary alcohols has been successfully performed under mild reaction conditions with ethynylbenziodoxole as the readily available alkynylation reagent. The desired C(sp3)–C(sp) coupling can smoothly occur with 4-CzIPN as a photocatalyst, affording a wide range of valuable alkynylation products bearing quaternary carbon centers in 37–84% yields.
Topics & Concepts
AlkynylationReagentTertiary alcoholsActivated carbonVisible spectrumPhotocatalysisChemistryQuaternary carbonCombinatorial chemistryPhotochemistryOrganic chemistryCatalysisMaterials scienceEnantioselective synthesisOptoelectronicsAdsorptionRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques