Modulation of gut microbiota and hypoglycemic/hypolipidemic activity of flavonoids from the fruits of<i>Lycium barbarum</i>on high-fat diet/streptozotocin-induced type 2 diabetic mice
Tingting Yang, Wangting Zhou, Weiqi Xu, Linwu Ran, Yamei Yan, Lu Lu, Jia Mi, Xiaoxiong Zeng, Youlong Cao
Abstract
were the dominant bacteria associated with T2DM. In conclusion, LBFs ameliorated HFD/STZ-induced T2DM in mice through three targets, including improving glucose and lipid metabolism, blocking pro-inflammatory cytokines, and regulating gut microbiota, except that the optimal dose of LBFs needs to be further explored.
Topics & Concepts
LyciumLachnospiraceaeStreptozotocinInternal medicineEndocrinologyGut floraProinflammatory cytokineChemistryDiabetes mellitusFatty liverMedicineBiochemistryInflammation16S ribosomal RNAFirmicutesDiseaseAlternative medicineGenePathologyGut microbiota and healthOral microbiology and periodontitis researchTraditional Chinese Medicine Studies