Fecal Metabolome Signature in the HIV-1 Elite Control Phenotype: Enrichment of Dipeptides Acts as an HIV-1 Antagonist but a <i>Prevotella</i> Agonist
Maike Sperk, Anoop T. Ambikan, Shilpa Ray, Kamal Singh, Flora Mikaeloff, Rafael Ceña-Díez, Ashwathy Narayanan, Jan Vesterbacka, Piotr Nowak, Anders Sönnerborg, Ujjwal Neogi
Abstract
HIV-1 elite controllers (EC) are a rare group among HIV-1-infected individuals who can naturally control viral replication for a prolonged period. Due to their heterogeneous nature, no universal mechanism could be attributed to the EC status; instead, several host and viral factors have been discussed as playing a role.
Topics & Concepts
BiologyMetabolomePhenotypeAgonistAntagonistHuman immunodeficiency virus (HIV)VirologyMetabolomicsGeneticsBioinformaticsReceptorGeneHIV Research and TreatmentHIV-related health complications and treatmentsGut microbiota and health