Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study
Taehee Kim, Hayoung Choi, Sang Hyuk Kim, Bumhee Yang, Kyungdo Han, Jin‐Hyung Jung, Bo‐Guen Kim, Dong Won Park, Ji‐Yong Moon, Sang‐Heon Kim, Tae‐Hyung Kim, Ho Joo Yoon, Dong Wook Shin, Hyun Lee
Abstract
Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD).This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls.Methods: We conducted a population-based cohort study of TB survivors and 1:1 age-and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017.We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls.Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization.TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls.Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54-1.73)and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81-2.27) in TB survivors.Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17-2.92).