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Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

Jennifer J. Schlezinger, Hunter M. Puckett, Jason D. Oliver, Greylin H. Nielsen, Wendy Heiger‐Bernays, Thomas F. Webster

2020Toxicology and Applied Pharmacology113 citationsDOIOpen Access PDF

Topics & Concepts

Perfluorooctanoic acidConstitutive androstane receptorCholesterol 7 alpha-hydroxylaseEndocrinologyInternal medicineFarnesoid X receptorCholesterolPeroxisome proliferator-activated receptorNuclear receptorDyslipidemiaLDL receptorBiologyHomeostasisChemistryLipoproteinReceptorMedicineGeneBiochemistryTranscription factorDiabetes mellitusPer- and polyfluoroalkyl substances researchBirth, Development, and HealthEstrogen and related hormone effects
Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet | Litcius