Heterogeneity of cell membrane structure studied by single molecule tracking
Gregory I. Mashanov, Tatiana A. Nenasheva, Alla Mashanova, Remigijus Lapė, N.J.M. Birdsall, Lucia G. Sivilotti, Justin E. Molloy
Abstract
tissue slices using a variety of membrane proteins, under different imaging conditions. In some cell types, we find no evidence for heterogeneity in mobility across the plasma membrane, but in others we find statistically significant differences with some regions of membrane showing significantly higher viscosity than others.
Topics & Concepts
MembraneTotal internal reflection fluorescence microscopeBiophysicsCell membraneMembrane structureChemistryMembrane proteinTracking (education)Lipid bilayerBiological systemBiologyBiochemistryPedagogyPsychologyLipid Membrane Structure and BehaviorAdvanced Fluorescence Microscopy TechniquesForce Microscopy Techniques and Applications