SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 <sup>+</sup> T cell activation in COVID-19 patients
Sunil Kumar Saini, Ditte Stampe Hersby, Tripti Tamhane, Helle Rus Povlsen, Susana Patricia Amaya Hernandez, Morten Nielsen, Anne Ortved Gang, Sine Reker Hadrup
Abstract
T cells, revealed a strong T cell activation in COVID-19 patients, while minimal T cell activation was seen in healthy individuals. We found that patients with severe disease displayed significantly larger SARS-CoV-2-specific T cell populations compared to patients with mild diseases and these T cells displayed a robust activation profile. These results further our understanding of T cell immunity to SARS-CoV-2 infection and hypothesize that strong antigen-specific T cell responses are associated with different disease outcomes.
Topics & Concepts
ImmunodominanceCoronavirus disease 2019 (COVID-19)GenomeBiologyVirologyEpitopeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)T cellCD82019-20 coronavirus outbreakGeneticsGeneAntigenDiseaseMedicineImmune systemPathologyInfectious disease (medical specialty)OutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesvaccines and immunoinformatics approaches