The immune contexture of primary central nervous system diffuse large B cell lymphoma associates with patient survival and specific cell signaling
Mélissa Alame, Emmanuel Cornillot, Valère Cacheux, Valérie Rigau, Valérie Costes‐Martineau, Vanessa Szablewski, Jacques Colinge
Abstract
Altogether, our study reveals that patient stratification according to immune subtypes, HLA status, and immune checkpoint molecule quantification should be considered prior to immune checkpoint inhibitor therapy. Moreover, TIM-3 protein should be considered an axis for future therapeutic development.
Topics & Concepts
Immune systemLymphomaCellCancer researchMedicineImmunologyBiologyGeneticsCNS Lymphoma Diagnosis and TreatmentLymphoma Diagnosis and TreatmentCancer Immunotherapy and Biomarkers