3D printed reduced graphene oxide-GelMA hybrid hydrogel scaffolds for potential neuralized bone regeneration
Xinwei Zhang, Hao Zhang, Yi Zhang, Yi Zhang, Huimin Huangfu, Yixin Yang, Qiuyue Qin, Yidi Zhang, Yidi Zhang, Yanmin Zhou
Abstract
, we found that the rGO/GelMA hydrogel exhibited the same low inflammatory response compared to the pure-GelMA group and the cell-only group, but surrounded by collagen fibers. Meanwhile, the osteogenic and neural proteins in the rGO/GelMA group were found to be highly expressed in immunohistochemistry and immunofluorescence. In this study, a scaffold material containing double cells was used to promote synergistic regeneration of nerves and bone, providing a promising strategy for the preparation of personalized and functionalized biomimetic bone material.
Topics & Concepts
Regeneration (biology)GrapheneScaffoldMaterials scienceBiomaterialBone healingBiomedical engineeringNanotechnologyCell biologyAnatomyBiologyMedicineGraphene and Nanomaterials ApplicationsBone Tissue Engineering Materials3D Printing in Biomedical Research