Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice
Abigail L. Tice, Joseph A. Laudato, Debra Ann Fadool, Bradley S. Gordon, Jennifer L. Steiner
Abstract
Herein, we demonstrate that acute alcohol intoxication immediately alters whole body metabolism coinciding with rapid changes in the skeletal muscle macronutrient gene signature for at least 48 h postbinge and that this response diverges from hepatic effects and those of a fasted animal.
Topics & Concepts
Skeletal muscleEndocrinologyMetabolismInternal medicineAlcoholGene expressionBiologyBinge drinkingMedicineGeneAlcohol consumptionBiochemistryAdipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsDiet and metabolism studies