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PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway

Heng-Jing Hu, Xiuheng Wang, Tianqing Zhang, Yao Liu, Zhengrong Chen, Zhi-Zhu Zhang, Hong Huang, Huifang Tang, Zhisheng Jiang

2022Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids19 citationsDOI

Topics & Concepts

ABCG1ABCA1Liver X receptorAMPKReverse cholesterol transportPhosphorylationChemistryFoam cellCholesterolLipid metabolismKinaseCell biologyBiologyProtein kinase AEndocrinologyBiochemistryLipoproteinNuclear receptorTranscription factorTransporterGeneCaveolin-1 and cellular processesCholesterol and Lipid MetabolismCancer, Lipids, and Metabolism
PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway | Litcius