Development and biological applications of sulfur–triazole exchange (SuTEx) chemistry
Adam L. Borne, Jeffrey W. Brulet, Kun Yuan, Ku‐Lung Hsu
Abstract
center in cell lysates and live cells. As a result of these features, SuTEx serves as an efficient platform for developing chemical probes with tunable bioactivity to study novel nucleophilic sites on established and poorly annotated protein targets. Here, we highlight a suite of biological applications for the SuTEx electrophile and discuss future goals for this enabling covalent chemistry.
Topics & Concepts
ElectrophileChemistryNucleophileBioconjugationCombinatorial chemistryChemical biologyCovalent bondAdductSulfonylMoietyOrganic chemistryBiochemistryCatalysisAlkylClick Chemistry and ApplicationsChemical Synthesis and AnalysisProtein Degradation and Inhibitors