Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film
Sanming Li, Liying Tang, Jing Zhou, Sonia Anchouche, Dian Li, Yiran Yang, Zhaolin Liu, Jieli Wu, Jiaoyue Hu, Yueping Zhou, Jia Yin, Zuguo Liu, Wei Li
Abstract
) could directly stimulate the proliferation of CEPCs in vivo and in vitro. Topical treatment of antioxidant L-glutathione preserved the over-proliferation of CEPCs and attenuated corneal epithelial defects in SD mice. Moreover, the activation of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway is essential to ROS-stimulated cell proliferation in CEPCs. However, long-term SD ultimately led to early manifestation of limbal stem cell deficiency.
Topics & Concepts
BiologyCell biologyReactive oxygen speciesProgenitor cellPI3K/AKT/mTOR pathwayStem cellCell growthCorneal epitheliumDownregulation and upregulationProtein kinase BCorneaEndocrinologyCancer researchImmunologySignal transductionBiochemistryNeuroscienceGeneOcular Surface and Contact LensCorneal Surgery and TreatmentsCorneal surgery and disorders