Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles <i>via</i> isocyanide insertion
Xu Wang, Jinping Fu, Jia-Xing Xie, Qing‐Hu Teng, Haitao Tang, Ying‐Ming Pan
Abstract
A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involves new C-N bond and C-O bond formation via palladium-catalyzed isocyanide insertion.
Topics & Concepts
IsocyanidePalladiumCatalysisChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryMulticomponent Synthesis of HeterocyclesSynthesis and biological activityCatalytic C–H Functionalization Methods