Palladium-Catalyzed Reductive Aminocarbonylation of Benzylammonium Triflates with <i>o</i>-Nitrobenzaldehydes for the Synthesis of 3-Arylquinolin-2(1<i>H</i>)-ones
Yongzhu Liu, Xinxin Qi, Xiao‐Feng Wu
Abstract
A palladium-catalyzed straightforward procedure for the synthesis of 3-arylquinolin-2(1H)-ones has been developed. The synthesis proceeds through a palladium-catalyzed reductive aminocarbonylation reaction of benzylic ammonium triflates with o-nitrobenzaldehydes, and a wide range of 3-arylquinolin-2(1H)-ones was obtained in moderate to good yields with very good functional group compatibility.
Topics & Concepts
PalladiumCatalysisChemistryCombinatorial chemistryCompatibility (geochemistry)AmmoniumMedicinal chemistryOrganic chemistryMaterials scienceComposite materialCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions